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JPTM > Ahead-of Print

doi: https://doi.org/10.4132/jptm.2016.11.11    [Epub ahead of print]
Mammary Carcinoma Arising in Microglandular Adenosis: A Report of Five Cases
Mimi Kim1, Milim Kim1,2, Yul Ri Chung1, So Yeon Park1,2
1Department of Pathology, Seoul National University College of Medicine, Seoul, Korea
2Department of Pathology, Seoul National University Bundang Hospital, Seongnam, Korea
Corresponding Author: So Yeon Park ,Email: sypmd@snu.ac.kr
Received: October 11, 2016;  Revised: November 8, 2016  Accepted: November 11, 2016.  Published online: April 4, 2017.
Mammary carcinoma arising in microglandular adenosis (MGA) is extremely rare, and MGA is regarded as a non-obligate precursor of triple-negative breast cancer. We report five cases of carcinoma arising in MGA of the breast. All cases showed a spectrum of proliferative lesions ranging from MGA to atypical MGA, ductal carcinoma in situ or invasive carcinoma. Immunohistochemically, all cases were triple-negative and expression of S-100 protein gradually decreased as the lesions progressed from MGA to atypical MGA and carcinoma. Three cases showed acinic cell differentiation with reactivity to α1-antitrypsin, and one case was metaplastic carcinoma. During clinical follow-up, one patient developed local recurrence. Carcinoma arising in MGA is a rare but distinct subset of triple-negative breast cancer with characteristic histologic and immunohistochemical findings.
Key Words: Fibrocystic breast disease; Breast; Carcinoma