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JPTM > Volume 44(5); 2010 > Article
The Korean Journal of Pathology 2010;44(5): 521-527.
doi: https://doi.org/10.4132/KoreanJPathol.2010.44.5.521
Application of Bethesda System for Reporting Thyroid Aspiration Cytology.
Kyungji Lee, Chan Kwon Jung, Kyo Young Lee, Ja Seong Bae, Dong Jun Lim, So Lyung Jung
1Department of Hospital Pathology, The Catholic University of Korea College of Medicine, Seoul, Korea. ckjung@catholic.ac.kr
2Department of Surgery, The Catholic University of Korea College of Medicine, Seoul, Korea.
3Department of Internal Medicine, The Catholic University of Korea College of Medicine, Seoul, Korea.
4Department of Radiology, The Catholic University of Korea College of Medicine, Seoul, Korea.
ABSTRACT
BACKGROUND: The Bethesda classification system for reporting on thyroid fine-needle aspiration (FNA) cytology was recently proposed by the National Cancer Institute, USA. We aimed to report our experience with applying this system for thyroid FNA, with a focus on comparing it with the four categorical system. METHODS: We retrospectively reviewed the 4,966 thyroid FNAs that were performed at the Seoul St. Mary's Hospital between October 2008 and September 2009. All the FNAs were classified according to the Bethesda system and the four tier system. RESULTS: The cytologic diagnoses of the Bethesda system included 10.0% unsatisfactory, 67.7% benign, 3.1% atypia of undetermined significance, 0.6% follicular neoplasm, 0.5% follicular neoplasm, Hurthle cell type, 5.1% suspicious for malignancy and 13.0% malignancy. Using four tier system, 10.1%, 67.6%, 9.3%, and 13% were diagnosed as unsatisfactory, negative for malignancy, atypical cells and malignancy, respectively. Of the 4,966 nodules, 905 were histologically confirmed. The specificity of the Bethesda system and the four tier system for diagnosing malignancy was 99.6% and 82.6%, respectively. CONCLUSIONS: The Bethesda system can classify indeterminate thyroid nodules into more detailed categories and provide clinicians with useful information for management.
Key Words: Biopsy, fine-needle; Thyroid neoplasms; Cytopathology; Diagnostic techniques and procedures