Journal of Pathology and Translational Medicine

Original Articles

Therapeutic Effects of Umbilical Cord Blood Derived Mesenchymal Stem Cell-Conditioned Medium on Pulmonary Arterial Hypertension in Rats: Jae Chul Lee, Choong Ik Cha, Dong-Sik Kim, Soo Young Choe; J Pathol Transl Med. 2015;49(6):472-480. Published online October 16, 2015; DOI: https://doi.org/10.4132/jptm.2015.09.11; Retraction in: J Pathol Transl Med 2016;50(4):325

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Mesenchymal Stromal Cells Promote Tumor Progression in Fibrosarcoma and Gastric Cancer Cells: Byunghoo Song, Bokyung Kim, Se-Ha Choi, Kyo Young Song, Yang-Guk Chung, Youn-Soo Lee, Gyeongsin Park; Korean J Pathol. 2014;48(3):217-224. Published online June 26, 2014; DOI: https://doi.org/10.4132/KoreanJPathol.2014.48.3.217

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Background

Extensive evidence has accumulated regarding the role of mesenchymal stromal cells (MSCs) in tumor progression, but the exact effects and mechanisms underlying this role remain unclear. We investigated the effects of MSC-associated tumor progression in MSC-sarcoma models and a gastric cancer metastatic model.

Methods

We conducted an in vitro growth kinetics assay and an in vivo tumor progression assay for sarcoma cells and gastric cancer cells in the presence or absence of MSCs.

Results

MSC-cocultured human fibrosarcoma cells (HT1080) showed accelerated growth compared with HT1080 alone (79- vs 37-fold change, p<.050). For HT1080, human MSC-coinjected tumors showed significantly greater and highly infiltrative growth compared to those of HT1080 alone (p=.035). For mouse fibrosarcoma cells (WEHI164), mouse MSC-coinjected tumors had greater volume than those of WEHI164 alone (p=.141). For rat sarcoma cells (RR1022), rat MSC-coinjected tumors exhibited greater volume and infiltrative growth than those of RR1022 alone (p=.050). For human gastric cancer cells (5FU), tumors of 5FU alone were compact, nodular in shape, and expansile with good demarcation and no definite lung metastatic nodules, whereas tumors grown in the presence of human MSCs showed highly desmoplastic and infiltrative growth and multiple lung metastasis.

Conclusions

We observed morphological evidence for MSC-associated tumor progression of fibrosarcomas and gastric cancer cells.

Citations

Citations to this article as recorded by

Transition between canonical to non-canonical Wnt signaling during interactions between mesenchymal stem cells and osteosarcomas
Asulin Masha, Ghedalia-Peled Noa Ben, Erez Ifat Cohen, Ventura Yvonne, Vago Razi
Open Journal of Orthopedics and Rheumatology.2020; : 037. CrossRef
Mesenchymal stem-cell therapy for perianal fistulas in Crohn’s disease: a systematic review and meta-analysis
F. Cheng, Z. Huang, Z. Li
Techniques in Coloproctology.2019; 23(7): 613. CrossRef
Human mesenchymal stromal cells do not promote recurrence of soft tissue sarcomas in mouse xenografts after radiation and surgery
PAOLA A. FILOMENO, KYUNG-PHIL KIM, NARA YOON, IRAN RASHEDI, VICTOR DAYAN, RITA A. KANDEL, XING-HUA WANG, TANIA C. FELIZARDO, ELLIOT BERINSTEIN, SALOMEH JELVEH, ANDREA FILOMENO, JEFFREY A. MEDIN, PETER C. FERGUSON, ARMAND KEATING
Cytotherapy.2018; 20(8): 1001. CrossRef
Review article: mesenchymal stromal cell therapy for inflammatory bowel diseases
C. Grégoire, C. Lechanteur, A. Briquet, É. Baudoux, F. Baron, E. Louis, Y. Beguin
Alimentary Pharmacology & Therapeutics.2017; 45(2): 205. CrossRef
Effect of hGC-MSCs from human gastric cancer tissue on cell proliferation, invasion and epithelial-mesenchymal transition in tumor tissue of gastric cancer tumor-bearing mice
Lin Song, Xin Zhou, Hong-Jun Jia, Mei Du, Jin-Ling Zhang, Liang Li
Asian Pacific Journal of Tropical Medicine.2016; 9(8): 796. CrossRef
BMP9 inhibits the growth and migration of lung adenocarcinoma A549 cells in a bone marrow stromal cell-derived microenvironment through the MAPK/ERK and NF-κB pathways
JING WANG, YAGUANG WENG, MINGHAO ZHANG, YA LI, MENGTIAN FAN, YANGLIU GUO, YANTING SUN, WANG LI, QIONG SHI
Oncology Reports.2016; 36(1): 410. CrossRef
Comparative proteomic analysis of fibrosarcoma and skin fibroblast cell lines
Ogunc Meral, Hamdi Uysal
Tumor Biology.2015; 36(2): 561. CrossRef
Involvement of Wnt/β-catenin signaling in the mesenchymal stem cells promote metastatic growth and chemoresistance of cholangiocarcinoma
Weiwei Wang, Wei Zhong, Jiahui Yuan, Congcong Yan, Shaoping Hu, Yinping Tong, Yubin Mao, Tianhui Hu, Bing Zhang, Gang Song
Oncotarget.2015; 6(39): 42276. CrossRef

Expressional Difference of RHEB, HDAC1, and WEE1 Proteins in the Stromal Tumors of the Breast and Their Significance in Tumorigenesis: Minseob Eom, Airi Han, Mi Jeong Lee, Kwang Hwa Park; Korean J Pathol. 2012;46(4):324-330. Published online August 23, 2012; DOI: https://doi.org/10.4132/KoreanJPathol.2012.46.4.324

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Abstract PDF

Background

Fibroadenoma (FA) and phyllodes tumor (PT) are stromal tumors of breast and are histologically similar. There are no established differences in tumorigenesis and oncogene expression among them. Ras homolog enriched in brain (RHEB) plays an important role in cell growth and cell-cycle control, histone deacetylase 1 (HDAC1) is an important factor in breast tumor progression and prognosis, and WEE1 homolog (WEE1) functions as a tumor suppressor. No studies on the expressional differences of these proteins in FA and PT have been reported to date.

Methods

The expression of these proteins in FA, PT, and normal breast was compared. We used 102 cases of FA and 25 cases of benign PT.

Results

In epithelial cells, the expression of RHEB, HDAC1, and WEE1 was lowest in PT, higher in FA, and most enhanced in normal breast. In addition, the expression of RHEB and HDAC1 was higher in the stromal cells of PT than in FA and normal breast.

Conclusions

Both epithelial and stromal cells of FA and PT express these proteins, which indicates that epithelial cells play an important role in the development of stromal tumors. In addition, the expressional differences of these proteins may be associated with the tumorigenesis of breast stromal tumors.

Citations

Citations to this article as recorded by

Gut microbiota-derived 3-phenylpropionic acid promotes intestinal epithelial barrier function via AhR signaling
Jun Hu, Jianwei Chen, Xiaojian Xu, Qiliang Hou, Jing Ren, Xianghua Yan
Microbiome.2023;[Epub] CrossRef
Genome-scale meta-analysis of breast cancer datasets identifies promising targets for drug development
Reem Altaf, Humaira Nadeem, Mustafeez Mujtaba Babar, Umair Ilyas, Syed Aun Muhammad
Journal of Biological Research-Thessaloniki.2021;[Epub] CrossRef
Wee1 Kinase: A Potential Target to Overcome Tumor Resistance to Therapy
Francesca Esposito, Raffaella Giuffrida, Gabriele Raciti, Caterina Puglisi, Stefano Forte
International Journal of Molecular Sciences.2021; 22(19): 10689. CrossRef
MiR-503 enhances the radiosensitivity of laryngeal carcinoma cells via the inhibition of WEE1
Huimin Ma, Rong Lian, Zhiyan Wu, Xiao Li, Wenfa Yu, Yun Shang, Xixia Guo
Tumor Biology.2017; 39(10): 101042831770622. CrossRef
Rheb phosphorylation is involved in p38-regulated/activated protein kinase-mediated tumor suppression in liver cancer
MIN ZHENG, SHENGBING ZANG, LINNA XIE, XUETING FANG, YU ZHANG, XIAOJIE MA, JINGFENG LIU, DEXIN LIN, AIMIN HUANG
Oncology Letters.2015; 10(3): 1655. CrossRef
Expression of CDK1Tyr15, pCDK1Thr161, Cyclin B1 (Total) and pCyclin B1Ser126 in Vulvar Squamous Cell Carcinoma and Their Relations with Clinicopatological Features and Prognosis
Zhihui Wang, Ana Slipicevic, Mette Førsund, Claes G. Trope, Jahn M. Nesland, Ruth Holm, Xin-Yuan Guan
PLOS ONE.2015; 10(4): e0121398. CrossRef
High expression of wee1 is associated with malignancy in vulvar squamous cell carcinoma patients
Gry Irene Magnussen, Ellen Hellesylt, Jahn M Nesland, Claes G Trope, Vivi Ann Flørenes, Ruth Holm
BMC Cancer.2013;[Epub] CrossRef

Neoplastic Stromal Cells of Intracranial Hemangioblastomas Disclose Pericyte-derived Mesenchymal Stromal Cells-like Phenotype.: Yong Han Jung, Jeong Kim, Bo Mi Kim, Eun Kyoung Kim, Mi Seon Kang, Soojin Jung, Young Il Yang, Shin Kwang Khang; Korean J Pathol. 2011;45(6):564-572.; DOI: https://doi.org/10.4132/KoreanJPathol.2011.45.6.564

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Abstract PDF

BACKGROUND
Stromal cells (SCs) of hemangioblastomas (HBs) have been regarded as true neoplastic components, but their ontogeny remains unclear. Convincing evidence suggests that embryonic mesenchymal cells may be the cells of origin of HBs. The aim of the present study was to investigate the immunophenotypic characteristics of neoplastic SCs using a set of markers against endothelial cells (ECs), vascular smooth muscle cells (vSMCs), mesenchymal stromal cells (MSCs), and pericytes.
METHODS
Intracranial HBs (n=46), angiolipoma (n=9), and pyogenic granuloma (n=11) were retrieved and the immunophenotypic profile of SCs was determined by immune stainings.
RESULTS
The MIB-1 labeling index was significantly higher in SCs compared to that of ECs and vSMCs, regardless of the type of lesion. The neoplastic SCs of HBs consistently expressed both MSC and pericyte markers, but did not express markers of ECs and vSMCs. Double immunofluorescent staining demonstrated that the neoplastic SCs of HBs expressing MSC or pericyte markers directly abutted onto the ECs of capillaries/venules.
CONCLUSIONS
The results suggest that the neoplastic SCs of HBs share the immunophenotypic profile and distribution with those of pericyte-derived MSCs. Thus, HBs might originate from a distinctive population of pericyte-derived MSCs in the central nervous system.

Citations

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Role of Endothelial-to-Mesenchymal Transition in the Pathogenesis of Central Nervous System Hemangioblastomas
Shigeki Takada, Masato Hojo, Noriyoshi Takebe, Kenji Tanigaki, Susumu Miyamoto
World Neurosurgery.2018; 117: e187. CrossRef
Endogenous Gastric-Resident Mesenchymal Stem Cells Contribute to Formation of Cancer Stroma and Progression of Gastric Cancer
Eun-Kyung Kim, Hye-Jung Kim, Young-Il Yang, Jong Tae Kim, Min-Young Choi, Chang Soo Choi, Kwang-Hee Kim, Jeong-Han Lee, Won-Hee Jang, Soon-Ho Cheong
Korean Journal of Pathology.2013; 47(6): 507. CrossRef

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