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- Invasive Cribriform Carcinoma Arising in Malignant Phyllodes Tumor of Breast: A Case Report
- Yoomi Choi, Kyoung Yul Lee, Min Hye Jang, Hyesil Seol, Sung-Won Kim, So Yeon Park
- Korean J Pathol. 2012;46(2):205-209. Published online April 25, 2012
- DOI: https://doi.org/10.4132/KoreanJPathol.2012.46.2.205
- 6,941 View
- 47 Download
- 6 Crossref
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Abstract
PDF Phyllodes tumor is an uncommon fibroepithelial neoplasm of the breast. And it is characterized by expanded stroma with increased cellularity and elongated epithelium-lined clefts. Mammary carcinomas within phyllodes tumors have been rarely reported. To date, however, no reports have described the invasive cribriform carcinoma arising in malignant phyllodes tumor. Here, we report a 62-year-old woman who presented with a large breast mass. Microscopically, the mass was a typical malignant phyllodes tumor showing well developed leaf-like architecture and stromal overgrowth with high cellularity and nuclear pleomorphism. In a portion of the tumor, however, the epithelial component showed a cribriform pattern of proliferation in the absence of myoepithelial cells, suggestive of the invasive cribriform carcinoma. To our knowledge, this is rare and it is difficult to make a differential diagnosis of it. Here, we report our case with a review of literatures.
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Citations
Citations to this article as recorded by
- Management of Concurrent Malignant Phyllodes Tumor and Invasive Breast Carcinoma
Jie Jane Chen, Iowis Zhu, Akshat Patel, Gregor Krings, Yunn-Yi Chen, Florence Yuen, Rita A. Mukhtar, Michelle Melisko, Lisa Singer, Catherine C. Park, Nicolas D. Prionas
Advances in Radiation Oncology.2024; 9(5): 101448. CrossRef - High-grade ductal carcinoma in-situ detected by microcalcification within borderline phyllodes tumor: Report of a case and literature review
Wing Nam Yuen, Joshua J.X. Li, Man Yi Chan, Gary M. Tse
Human Pathology Reports.2023; 31: 300697. CrossRef - Cribriform carcinoma arising in a benign phyllodes tumor
EliaShazniza Shaaya, Nurwahyuna Rosli, Nurismah MD Isa
Journal of Research in Medical Sciences.2023; 28(1): 16. CrossRef - Unexpectedly High Coexistence Rate of In Situ/Invasive Carcinoma In Phyllodes Tumors. 10-Year Retrospective and Review Study
Öykü Dila Gemci, Serdar Altınay, Rümeysa İlbar Tartar, Sina Ferahman
European Journal of Breast Health.2022; 18(4): 343. CrossRef - A Case of Phyllodes Tumor Combined with Lobular Carcinoma of the Breast with Microinvasion
Daiki IMANISHI, Satoru NODA, Tsutomu TAKASHIMA, Yukie TAUCHI, Shinya NOMURA, Hiroshi OHTANI, Noriko SAKAIDA
Nihon Rinsho Geka Gakkai Zasshi (Journal of Japan Surgical Association).2022; 83(12): 2049. CrossRef - Invasive ductal carcinoma within borderline phyllodes tumor with lymph node metastases: A case report and review of the literature
DI WU, HAIPENG ZHANG, LIANG GUO, XU YAN, ZHIMIN FAN
Oncology Letters.2016; 11(4): 2502. CrossRef
- Management of Concurrent Malignant Phyllodes Tumor and Invasive Breast Carcinoma
- Correlation between Tumor Angiogenesis and Metastasis in Invasive Breast Carcinoma.
- Nam Hoon Kim, Moon Hyang Park
- Korean J Pathol. 1995;29(6):740-745.
- 1,339 View
- 14 Download
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Abstract
PDF
- Tumor angiogenesis(TA) refers to the growth of new vessels toward and within a tumor. TA is necessary both at the beginning and at the end of the metastatic cascade of events. Recently, experimental evidence suggests that the growth of a tumor beyond a certain size requires angiogenesis. To investigate how tumor angiogenesis correlates with metastases in breast carcinoma, the microvessels were counted (per 200 / field) in the most active areas of neovas-cularization by two investigators. The microvessels within breast carcinoma were highlighted by in imunohistochemical staining for factor VIII-related antigen. Microvessel count(MVC) in node-positive carcinoma(59.66=35) was significantly higher than in node-negative carcinoma(44.76=17)(p=0.009). MVC was also statistically correlated with tumor size and stage, but not with histologic grading, DNA ploidy, or hormonal receptors(estro-gen and progesterone). MVC in invasive breast carcinoma may be one of many prognostic predictors of node-positive breast carcinoma. Assessment of tumor angiogenesis may therefore be valuable in selecting patients with early breast carcinoma for aggressive therapy.
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