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Case Study
- Primary Necrobiotic Xanthogranulomatous Sialadenitis with Submandibular Gland Localization without Skin Involvement
- Myunghee Kang, Na Rae Kim, Dong Hae Chung, Jae Yeon Seok, Dong Young Kim
- J Pathol Transl Med. 2019;53(4):261-265. Published online January 16, 2019
- DOI: https://doi.org/10.4132/jptm.2019.01.08
- 5,675 View
- 158 Download
- 1 Web of Science
- 5 Crossref
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Abstract
PDF - Necrobiotic xanthogranulomatous reaction is a multiorgan, non-Langerhans cell histiocytosis with an unknown etiology. Occurrence in the salivary gland is extremely rare. We recently identified a case of necrobiotic xanthogranulomatous sialadenitis in a 73-year-old Korean woman who presented with a painless palpable lesion in the chin. There was no accompanying cutaneous lesion. Partial resection and subsequent wide excision with neck dissection were performed. Pathological examination showed a severe inflammatory lesion that included foamy macrophages centrally admixed with neutrophils, eosinophils, lymphocytes, plasma cells, and scattered giant cells, as well as necrobiosis. During the 12-month postoperative period, no grossly remarkable change in size was noted. Necrobiotic xanthogranulomatous inflammation may be preceded by or combined with hematologic malignancy. Although rare, clinicians and radiologists should be aware that an adhesive necrobiotic xanthogranuloma in the salivary gland may present with a mass-like lesion. Further evaluation for hematologic disease and close follow-up are needed when a pathologic diagnosis is made.
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Citations
Citations to this article as recorded by
- Five Cases of Xanthogranulomatous Sialadenitis
Satoshi Kiyama, Hiroyuki Iuchi, Kotoko Ito, Kengo Nishimoto, Tsutomu Matsuzaki, Masaru Yamashita
Practica Oto-Rhino-Laryngologica.2022; 115(4): 315. CrossRef - Xanthogranulomatous change in a pleomorphic adenoma: An extremely rare variant/degenerative change. Is it fine needle aspiration induced?
Mukta Pujani, Dipti Sidam, Kanika Singh, Aparna Khandelwal, Khushbu Katarya
Diagnostic Cytopathology.2021;[Epub] CrossRef - A Case of Xanthogranulomatous Sialadenitis with Facial Palsy Mimicking Malignancy
Sang Hyun Kim, Sun Woo Kim, Sang Hyuk Lee
Korean Journal of Otorhinolaryngology-Head and Neck Surgery.2021; 64(6): 422. CrossRef - Xanthogranulomatous Sialadenitis, an Uncommon Reactive Change is Often Associated with Warthin’s Tumor
Lihong Bu, Hui Zhu, Emilian Racila, Sobia Khaja, David Hamlar, Faqian Li
Head and Neck Pathology.2020; 14(2): 525. CrossRef - A Case of Xanthogranulomatous Sialadenitis of the Sublingual Gland:A Review of Literature
Naoya KITAMURA, Seiji OHNO, Tetsuya YAMAMOTO
Journal of Japanese Society of Oral Medicine.2019; 25(1): 20. CrossRef
- Five Cases of Xanthogranulomatous Sialadenitis
Original Article
- Neoplastic Diseases of the Hematopoietic and Lymphoid Tissues: New World Health Organization Classification.
- Woo Ick Yang
- Korean J Pathol. 2002;36(3):137-145.
- 1,652 View
- 18 Download
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Abstract
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- Encouraged by the success of the Revised European American Classification of Lymphoid Neoplasms (REAL) which was published in 1994 by th International Lymphoma Study Group (ILSG), the European Association of Pathologists and the Society for Hematopathology have started a collaborative classification project in 1995 under the auspices of World Health Organization (WHO). The two collaborators employed the same consensus building process used by ILSG for the REAL to the classification of myeloid, histocytic/dendritic, and mast cell neoplasms and listed real biologic entities defined by morphologic, immunophenotypic, cytogenetic, and and clinical findings. In contrast to the REAL, Clinical Advisory Committee composed of expert hematologists and oncologists evaluated the clinical relevance of the classification scheme proposed by the pathologists before the publication of new WHO classification of hematologic malignancies. While the classification of lymphoid neoplasms contained minor changes compared with the REAL, there were major changes in the classification system of myeloid neoplasms compared with the previously used French-American-British (FAB) classification. The new WHO classification of hematologic malignancies, published last year, is a product of the first true worldwide consensus among leading pathologists and clinicians alike, and it overcomes the drawbacksof old fashioned classification schemes; therefore, we can expect progress in the understanding and treatment of hematologic malignancies.
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