Journal of Pathology and Translational Medicine

Case Study

Oncocytic Lipoadenoma: A Rare Case of Parotid Gland Tumor and Review of the Literature: Chen-lin Chi, Tseng-tong Kuo, Li-yu Lee; J Pathol Transl Med. 2015;49(2):144-147. Published online March 12, 2015; DOI: https://doi.org/10.4132/jptm.2014.02.10

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Oncocytic lipoadenoma is a rare tumor, with only 18 cases having been reported since the first in 1998. We encountered a case of oncocytic lipoadenoma presenting as a slowly growing parotid mass in a 71-year-old man. This tumor is characteristically comprised of a mixture of oncocytes and adipocytes. The present case is one of five reported cases of oncocytic lipoadenoma showing sebaceous differentiation. The results of immunohistochemical study with DOG1 antibody supported the origination of this tumor in the striated duct.

Citations

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Oncocytic sialolipoma of parotid gland: Case report and literature review
VenuPatel Sureja, KoyyeRavindranath Tagore
Indian Journal of Pathology and Microbiology.2023; 66(3): 591. CrossRef
Complex Component of Oncocytic and Non-Oncocytic Lipoadenomas in the Parotid Gland: A Case Report
Fuyuki Sato, Takashi Nakajima, Takashi Sugino
Diagnostics.2021; 11(8): 1478. CrossRef
Oncocyitic lipoadenoma of the parotid gland
Renato PIANTANIDA, Alberto CARANTI, Adele CHIESA, Jessica BARIZZI, Ulrike PERRIARD, Filippo BARUCCA, Antonio PELLANDA
Otorinolaringologia.2021;[Epub] CrossRef
A case of oncocytic lipoadenoma of the submandibular gland and its diagnostic cytology challenges
Khaled A. Murshed, Ammar Khalafalla, Belal Alani, Hanan Farghaly, Moustafa Alkhalil
Diagnostic Cytopathology.2020; 48(4): 364. CrossRef
An extremely rare case of giant oncocytic adenolipoma of the parotid gland
Dipesh Shakya, Ajit Nepal
Clinical Case Reports.2020; 8(12): 2390. CrossRef
A rare cause of primary hyperparathyroidism: Parathyroid lipoadenoma
Sabri Özden, Servet Güreşci, Barış Saylam, Gül Dağlar
Auris Nasus Larynx.2018; 45(6): 1245. CrossRef
Oncocytic osteolipoadenoma of the submandibular gland
Domenico Corradi, Rodolfo Monaco, Giulia D'Angelo, Paola Bini, Teore Ferri, Enrico M Silini
Histopathology.2016; 69(1): 148. CrossRef

Original Article

Usefulness of DOG1 Expression in the Diagnosis of Gastrointestinal Stromal Tumors.: Jun Mo Kim, Aeri Kim, Joon Hyuk Choi, Young Kyung Bae; Korean J Pathol. 2010;44(2):141-148.; DOI: https://doi.org/10.4132/KoreanJPathol.2010.44.2.141

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Abstract PDF

BACKGROUND
Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors in the gastrointestinal tract. Expression of KIT protein (CD117) is an important diagnostic criterion of GIST. However, about 5% of GISTs are CD117 negative. Discovered on GIST 1 (DOG1) was introduced recently as a promising marker for GIST. We tested this new antibody in 105 GISTs tissue specimens, including 6 cases of metastatic GISTs, to determine the usefulness of DOG1 expression in the diagnosis of GISTs.
METHODS
We performed immunohistochemical (IHC) staining for DOG1 and CD117 on tissue microarrays that included 70 gastric GISTs, 29 small intestinal GISTs, 6 metastatic GISTs, 14 gastric leiomyomas and 16 gastric schwannomas.
RESULTS
DOG1 was positive in 98.1% (103/105) of GISTs and CD117 was positive in 97.1% (102/105) of GISTs. Only 1 case was negative for both markers. Two (66.7%) out of 3 GISTs tested CD117 negative were tested DOG1 positive. All leiomyomas and schwannomas were negative for both DOG1 and CD117.
CONCLUSIONS
DOG1 was highly expressed in GIST including CD117 negative cases. Adding DOG1 testing to the IHC panel for diagnosing GIST will help to identify GIST patients who are CD117 negative but may otherwise benefit from targeted therapy.

Citations

Citations to this article as recorded by

Gastrointestinal tract spindle cell tumors with interstitial cells of Cajal: Prevalence excluding gastrointestinal stromal tumors
So Jung Lee, Chung Su Hwang, Ahrong Kim, Kyungbin Kim, Kyung Un Choi
Oncology Letters.2016; 12(2): 1287. CrossRef

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