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Case Study
- Atypical femoral neck fracture after prolonged bisphosphonate therapy
- Kwang-kyoun Kim, Young-wook Park, Tae-hyeong Kim, Kyung-deok Seo
- J Pathol Transl Med. 2020;54(4):346-350. Published online June 29, 2020
- DOI: https://doi.org/10.4132/jptm.2020.05.14
- Correction in: J Pathol Transl Med 2020;54(5):435
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- 7 Web of Science
- 7 Crossref
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Abstract
PDF - Of the drugs developed to prevent and treat osteoporosis, bisphosphonate has played a very important role in preventing osteoporotic fractures. However, case reports describing atypical femoral fractures in patients using long-term bisphosphonates have emerged. The majority of atypical femur fractures occurs in the lateral aspect of the subtrochanteric or femur diaphysis, which is explained by accumulation of tensile stress in these areas. Although the superior cortex of the femur neck withstands maximum tensile stress, to our knowledge, there have been only two reports (three cases) of atypical femoral neck fracture. In addition, none of those case reports revealed detailed pathology related to suppressed bone turnover rate. We encountered an incomplete femoral neck fracture and diagnosed it as “atypical” on the basis of the patient’s lack of trauma and medication history and pathological findings. For patients with groin pain, minimal or no trauma, and a history of long-term bisphosphonate use, an atypical femoral neck fracture should be considered.
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Citations
Citations to this article as recorded by
- Is there genetic susceptibility for atypical femoral fractures?
Maximilian Ellacott, Hüseyin Bilgehan Çevik, Peter V. Giannoudis
Injury.2024; 55(2): 111312. CrossRef - Clinical value of quantitative parameters of MSCT in the diagnosis of occult femoral neck fractures
Yongzhong Xu, Shan Gao
Biotechnology and Genetic Engineering Reviews.2023; : 1. CrossRef - Femoral neck stress fracture return to activity and the effect of metabolic dysfunction on recovery: A systematic review
Kristine Yang, Senthil Sambandam, Matthew J. Yan, Michael Huo
Journal of Orthopaedics.2023; 43: 79. CrossRef - Association of atypical femoral fracture location and lower limb mechanical axis: a computed tomography-based finite element analysis
Donghwan Hwang, Chul-Ho Kim, Yongkoo Lee, Ji Wan Kim
Osteoporosis International.2022; 33(6): 1285. CrossRef - Bilateral Bisphosphonate-related Atypical Femoral Neck Fracture in a Patient with Familial Mediterranean Fever: A Case Report
Sibel Balıkçı, Bilinç Doğruöz Karatekin
Turkish Journal of Osteoporosis.2022; 28(1): 74. CrossRef - Clinical Outcomes and Radiologic Characteristics of Insufficiency Femoral Neck Fracture in Elderly Patients
Hee-Uk Ye, Kyung-Jae Lee, Byung-Woo Min, Kyung-Hwan Lim, Beom-Soo Kim, Young-Hoon Kim
Journal of the Korean Fracture Society.2021; 34(1): 1. CrossRef - Ibandronic acid
Reactions Weekly.2020; 1827(1): 165. CrossRef
- Is there genetic susceptibility for atypical femoral fractures?
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